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The role of CD47 in cell migration was first demonstrated for neutrophils, the place CD47 blocking antibodies inhibited transmigration of neutrophils and monocytes via the endothelium. These results had been shown to be dependent on avb3 integrins, which work together with and are activated by CD47 at the plasma membrane. Originally found by Irving Weissman’...
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4 months agoSeni - Barang Koleksi1376 people viewed